[TMG] Re: pan sinusitis anti-biotic drugs and stomach pain :(

[supat at supat.eu.org]

I stop using it since today because of too much diarrhea :(
more info i got is below:


http://www.flexyx.com/C/Cefspan.html

Flexyx drugs: Cefspan

Cefspan - General Information:
Cefspan, an antibiotic, is a third-generation cephalosporin like 
ceftriaxone and cefotaxime. Cefspan is highly stable in the presence of 
beta-lactamase enzymes. As a result, many organisms resistant to 
penicillins and some cephalosporins due to the presence of 
beta-lactamases, may be susceptible to cefixime. The antibacterial effect 
of cefixime results from inhibition of mucopeptide synthesis in the 
bacterial cell wall.

Related offer from MedStore:
Suprax	Generic Suprax (Cefixime) - 100mg 30 pills for $53.40
"Suprax (Cefixime) is a cephalosporin antibiotic used to treat infections 
caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, 
lung, throat, and urinary tract infections. Antibiotics will not work for 
colds, flu, or other viral infections."
Pharmacology:
Cefspan, an antibiotic, is a third-generation cephalosporin like 
ceftriaxone and cefotaxime. Cefspan is highly stable in the presence of 
beta-lactamase enzymes. As a result, many organisms resistant to 
penicillins and some cephalosporins due to the presence of 
beta-lactamases, may be susceptible to cefixime. The antibacterial effect 
of cefixime results from inhibition of mucopeptide synthesis in the 
bacterial cell wall.
Cefspan for patients

Cefixime is a cephalosporin antibiotic used to treat bacterial infections. 
Take at regular intervals and complete the entire course of therapy. Do 
not take this medication if you are allergic to any type of penicillin or 
cephalosporin. Notify your physician if you are pregnant or nursing. This 
antibiotic may decrease the effectiveness of birth control pills; use 
another form of birth control while taking this medication. Shake the 
suspension well before each use and store it in the refrigerator. May 
cause nausea, vomiting or diarrhea; notify your physician if these occur. 
Take with food or milk to avoid stomach upset. Cefixime may cause a 
false-positive reaction for nonspecific urine glucose tests in patients 
with diabetes. This medication does not interfere with enzyme-based urine 
glucose tests.
Cefspan Interactions

Carbamazepine: Elevated carbamazepine levels have been reported in 
postmarketing experience when SUPRAX is administered concomitantly. Drug 
monitoring may be of assistance in detecting alterations in carbamazepine 
plasma concentrations.

Warfarin and Anticoagulants: Increased prothrombin time, with or without 
clinical bleeding, has been reported when cefixime is administered 
concomitantly.

Drug/Laboratory Test Interactions

A false-positive reaction for ketones in the urine may occur with tests 
using nitroprusside but not with those using nitroferricyanide.

The administration of SUPRAX may result in a false-positive reaction for 
glucose in the urine using ClinitestO**, Benedictis solution, or Fehlingis 
solution. It is recommended that glucose tests based on enzymatic glucose 
oxidase reactions (such as Clinistix(R)** or Tes-TapeO**) be used. A 
false-positive direct Coombs test has been reported during treatment with 
other cephalosporin antibiotics; therefore, it should be recognized that a 
positive Coombs test may be due to the drug.
Cefspan Contraindications

SUPRAXO is contraindicated in patients with known allergy to the 
cephalosporin group of antibiotics.
Additional information about Cefspan
Cefspan Indication: For use in the treatment of the following infections 
when caused by susceptible strains of the designated microorganisms: (1) 
uncomplicated urinary tract infections caused by Escherichia coli and 
Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae 
(beta-lactamase positive and negative strains), Moraxella catarrhalis 
(most of which are beta-lactamase positive), and S. pyogenes, (3) 
pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis 
and acute exacerbations of chronic bronchitis caused by Streptococcus 
pneumoniae and Haemophilus influenzae (beta-lactamase positive and 
negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) 
caused by Neisseria gonorrhoeae (penicillinase- and 
non-penicillinase-producing strains).
Mechanism Of Action: Like all beta-lactam antibiotics, cefixime binds to 
specific penicillin-binding proteins (PBPs) located inside the bacterial 
cell wall, causing the inhibition of the third and last stage of bacterial 
cell wall synthesis. Cell lysis is then mediated by bacterial cell wall 
autolytic enzymes such as autolysins; it is possible that cefixime 
interferes with an autolysin inhibitor.
Drug Interactions: Probenecid Probenecid increases the antibiotic's level
Food Interactions: Preferably on an empty stomach, rate of absorption is 
decreased but extenet of absorption remains the same: not really 
problematic.
Generic Name: Cefixime
Synonyms: Cefixima [Spanish]; Cefixime Anhydrous; Cefiximum [Latin]; 
Cefixim
Where to order Cefixime (and Cefspan analogs) online:
Drug Category: Anti-Bacterial Agents; Cephalosporins
Drug Type: Small Molecule; Approved
Other Brand Names containing Cefixime: CFIX; Cefixoral; Cefspan; Cephoral; 
Oroken; Suprax; Unixime;
Absorption: About 40%-50% absorbed orally whether administered with or 
without food, however, time to maximal absorption is increased 
approximately 0.8 hours when administered with food.
Toxicity (Overdose): Symptoms of overdose include blood in the urine, 
diarrhea, nausea, upper abdominal pain, and vomiting.
Protein Binding: 65% (concentration independent)
Biotransformation: Hepatic. Approximately 50% of the absorbed dose is 
excreted unchanged in the urine in 24 hours.
Half Life: 3-4 hours (may range up to 9 hours). In severe renal impairment 
(5 to 20 mL/min creatinine clearance), the half-life increased to an 
average of 11.5 hours.
Dosage Forms of Cefspan: Tablet Oral
Powder, for suspension Oral
Chemical IUPAC Name: 
(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethyloxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic 
acid
Chemical Formula: C16H15N5O7S2
Cefixime on Wikipedia: http://en.wikipedia.org/wiki/Cefixime
Organisms Affected: Enteric bacteria and other eubacteria


On Mon, 11 Aug 2008, supat at supat.eu.org wrote:

>
> Dear Dr. Thanit,
>
> As you may know that I have serious sinusitis.
> Recently KPS director doctor change pan sinusitis anti-biotic drugs from one 
> form to another form because I complain to him that the drug seem to be 
> uneffective.
>
> Both earlier drug and today drug seem to have no effect on my sinus but has 
> its main effect is to cause my stomach pain and diarrhea instead.
>
> I wonder why medicine to day cannot cure any thing but cause bad effect to 
> patient organ instead ? :(
>
> Regards,
> supat
>
> On Sun, 10 Aug 2008, Thanit Hasadsri wrote:
>
>> Âé͹ä»ÍèÒ¹¢Í§·ÕèÁÒ à¢ÒÍéÒ§ÇèÒ ÁÒ¨Ò¡.....
>> "ÈÔÅÒ¨ÒÃÖ¡"ã¹à¢µÁËÒÇÔËÒà ÊǹÁĤ·ÒÂÇѹ »ÃÐà·ÈÍÔ¹à´Õ ¨Ò¡àÍ¡ÊÒÃà¼Âá¾Ãè¸ÃÃÁ 
>> ¢Í§¾ÃÐà´ª¾ÃФس "¾ÃÐÃÒªÊØ·¸Ô­Ò³Á§¤Å (¨ÃÑ­ °Ôµ¸ÑÁâÁ)ÇÑ´ÍÑÁ¾ÇѹÍÓàÀ;ÃËÁºØÃÕ 
>> ¨Ñ§ËÇÑ´ÊÔ§ËìºØÃÕ.....
>> ¡çäÁè¹èÒàª×èÍ à¾ÃÒÐ äÁèà¤Âä´éÂÔ¹ ÈÔÅÒ¨ÒÃÖ¡ Ẻ¹Õé 
>> áµè¹èÒ¨ÐÁÒ¨Ò¡¤ÑÁÀÕÃì·Õ褹âºÃÒ³áµè§¢Ñé¹ÁÒ
>> â´Âàª×èÍÇèÒ ¾Ø·¸ÈÒÊ¹Ò ¨ÐÁÕ á¤è õ ¾Ñ¹»Õ «Ö觼Á äÁèàª×èÍ áÅÐ äÁèÇÔµ¡ 
>> à¾ÃÒШйҹáµèä˹
>> àÃÒ¡çà»ÅÕè¹äÁèä´é áµèà˵ءÒóìµèÒ§æ¹Ñé¹ àÃÒÍÒ¨à»ÅÕè¹ä´é ¶éÒàÃÒ·ÓµÑÇàͧ 
>> ¤¹ã¹¤Ãͺ¤ÃÑÇãËé´Õ ¤ÃѺ
>> 
>> 
>> --- On Thu, 8/7/08, supat at supat.eu.org <supat at supat.eu.org> wrote:
>> 
>>> From: supat at supat.eu.org <supat at supat.eu.org>
>>> Subject: Re: [TMG] fwd
>>> To: "Thai Mailing Group" <thai-l at thai-l.net>
>>> Date: Thursday, August 7, 2008, 8:40 PM
>>> I listen similar stories several time since 2497
>>> BUT this is the first time I got it alphabetically in
>>> words.
>>> 
>>> IMO: it is most likely to be true because now several signs
>>> in our lord
>>> predictions did already happen.
>>> 
>>> I assure that most bosses in this world are bad bosses :(
>>> The same happen to TH and USA.
>>> 
>>> zxc555
>>> 
>>>> 
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>>> 
>>>> 
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